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Histamine intolerance (HI, histaminosis) is a controversial clinical picture among experts. In histamine intolerance, the body reacts to an increased amount of histamine with intolerance reactions. This substance occurs naturally in the body, but is also contained in many foods.
What is histamine?
Histamine is an endogenous tissue hormone and a messenger substance that occurs naturally in the body. It is produced by the body itself and is found throughout the organism. Biochemically, histamine belongs to the biogenic amines. Biogenic amines are involved in many different important body functions. For example, they regulate blood pressure, stimulate the production of gastric juices, increase intestinal motility and ensure a balanced sleep-wake rhythm. They also play an active role in immune defense. For example, when a part of the body swells due to an injury, it is due to the action of histamine. Histamine is also involved in the development of itching and pain - and in many allergic reactions.
Histamine is also contained in many foods. Particularly long-matured products such as red wine and hard cheese contain a lot of histamine. Other foods such as pineapple and chocolate belong to the so-called histamine liberators: although they are low in histamine, they also release it in the intestine. Foods that contain or release histamine can normally be consumed without problems, as the body's own enzyme DiAminOxidase (DAO) breaks down histamine.
Normally, the organism is able to tolerate larger amounts of histamine. In the case of histamine intolerance, however, even small amounts can cause symptoms.
Why do some people not tolerate histamine?
Due to the lack of the enzyme DAO, the body can no longer sufficiently break down histamine from food. The histamine problems can be both temporary (temporary) and permanent (chronic or permanent).
Fish poisoning, histamine-rich food, stress or strong physical strain can cause a temporary excess of histamine in the organism. If the body then does not have a sufficient amount of DAO, various symptoms can occur. Alcohol or medications - even in small amounts - can also temporarily block DAO from working. Such a temporary enzyme deficiency can affect anyone and cause symptoms.
The formation of DAO enzymes can also be influenced genetically or as a result of chronic inflammatory bowel diseases such as Crohn's disease or celiac disease. In this case, there is a permanent (permanent) enzyme deficiency.
Symptoms
The symptoms can be very diverse, e.g. Reddened skin with a feeling of heat (flush), itching, hives (urticaria), palpitations, headaches, migranes, dizziness, stuffy or runny nose, breathing difficulties, sore throat, asthma, diarrhea, abdominal pain, constipation, nausea/vomiting, stomach stings, heartburn, high blood pressure, low blood pressure, palpitations, arrhythmias, menstrual cramps, water retention, bone marrow edema, joint pain, conditions of exhaustion, fatigue, sleep disturbances, confusion, nervousness, depressed moods, etc.
Some patients show only single symptoms (such as skin redness with itching). In others, however, histaminosis manifests itself with symptoms in several parts of the body. This is because a wide variety of cells and organs have docking sites (receptors) for histamine. These include smooth muscle cells (in the stomach and intestinal walls, in the bronchi and uterus, in the blood vessel walls, etc.), glandular cells, nerve cells and cells of the immune system (e.g. mast cells).
Diet can trigger symptoms
Histamine and its derivatives are present in almost all foods and some beverages. However, the histamine content varies considerably and can be influenced by processing methods such as ripening or fermentation.
The consumption of histamine-rich foods increases the histamine concentration in the body. If histamine breakdown cannot be increased accordingly, histamine metabolism is out of balance and symptoms may occur. A low histamine diet is recommended for people with histamine intolerance.
If you're not sure which products are low in histamine, simply scan the barcode with your TIOLI app and find out if other people with histamine intolerance have tolerated that product and if the product contains ingredients that are intolerant to you.
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Note: The information on this page has been carefully researched, but we do not guarantee its completeness or accuracy. If you have any health problems, please consult your doctor.
*The links on this website are so-called affiliate links. If you click on such an affiliate link and make a purchase through this link, we will receive a commission from the respective online store or provider. The price does not change for you. As an Amazon partner we earn on qualified sales.
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Histaminikus - low-histamine, gluten-free and FODMAP-conscious organic products of the highest quality
Thomas and Michaela are researchers, visionaries, discoverers, encouragers, health consultants and founders of Histaminikus. Their Histaminikus products are developed and lovingly produced according to their own recipes especially for people with intolerances. Their mission, together with their fantastic team, is to develop delicious foods according to their own recipes that are not only low in histamine and gluten-free, but also taste really delicious.
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Fructose intolerance - symptoms, diagnosis & treatment
Fructose intolerance is a rare genetic disorder that affects the way the body processes fructose, a type of sugar found in many foods and beverages. The disorder is caused by a deficiency of the enzyme aldolase B, which is needed to break down fructose in the liver. Symptoms of fructose intolerance include abdominal pain, bloating, diarrhea and nausea. Treatment for fructose intolerance includes a strict low-fructose diet and, in some cases, vitamin and mineral supplements and medication.
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Painkillers for histamine intolerance
Many people with histamine intolerance are initially unaware that many painkillers are also unsuitable. This is because most painkillers contain so-called histamine liberators. These are substances that release the body's own histamine in mast cells. DAO blockers can also be a problem. DAO is the main degradation pathway in the intestine. Certain substances can inhibit DAO enzyme activity by their presence in the body. As you can see, the question "Which painkillers for histamine intolerance?" is not so easy to answer. On the one hand, it is necessary to check whether the active ingredient is tolerated. On the other hand, it is also necessary to check which excipients are contained in the medication.
